In 1961 a group of researchers from Princeton University were working at Friday Harbor near Seattle, Washington. They noticed that a constant stream of glowing jellyfish floated by their lab each day and decided to study this specific species of jellyfish called Aequorea victoria to determine what caused them to glow. Led by Osamu Shimomura, PH.D, the group developed an extraction process and eventually discovered that the cause of the glowing jellyfish was a specific ingredient. Researchers began using this ingredient, apoaequorin, in many experiments. Decades of research and laboratory use then followed.

One of the advantages of apoaequorin is its low risk of side effects. The majority of users do not experience adverse reactions when taking this supplement as directed. However, it's essential to follow recommended dosages and consult with a healthcare professional before use.